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September 7, 2010



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Appropriate and Safe Dosing of
Atypical Antipsychotics


Published: November 1, 2002
ACPE Lesson Expires: November 1, 2005



Provided through an unrestricted educational grant from



 

REFERENCES

  1. Gerlach J. Improving outcome in schizophrenia: the potential importance of EPS and neuroleptic dysphoria. Ann Clin Psychiatry. 2002;14:47-57.

  2. Marder SR. Approaching the adherence challenge. Program and abstract of the American Psychiatric Association 155th Annual Meeting; May 18-23, 2002; Philadelphia, Pa. Industry-supported Symposium No. 17A.

  3. Casey DE. Adverse effects profile of new antipsychotic agents. Program and abstract of the American Psychiatric Association 155th Annual Meeting; May 18-23, 2002; Philadelphia, Pa. Industry-supported Symposium No. 35C.

  4. Kane JM. Dose selection and comparator drugs in schizophrenia research. J Clin Psychiatry. 2001;62:29-32; discussion 33-34.

  5. Williams R. Optimal dosing with risperidone: updated recommendations. J Clin Psychiatry. 2001;62:282-289.

  6. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, 4th ed. Washington, DC: American Psychiatric Press; 1994.

  7. Dixon LB, et al. Conventional antipsychotic medications for schizophrenia. Schizophr Bull. 1995;21(4):1567-1577.

  8. Clozaril® (package insert). East Hanover, NJ: Novartis Pharmaceuticals Corporation; March 1998.

  9. Beasley CM, Tollefson GD, Tran PV. Efficacy of olanzapine: an overview of pivotal clinical trials. J Clin Psychiatry. 1997;58:7-12.

  10. Beasley CM Jr, Sanger T, Satterlee W, et al. Olanzapine versus placebo: results of a double blind, fixed-dose olanzapine trial. Psychopharmacology (Berl). 1996;124:159-167.

  11. Seroquel® (package insert). Wilmington, Del: Zeneca Pharmaceuticals; November 1997.

  12. Geodon® (package insert). New York, NY: Pfizer; February 2002.

  13. Stahl SM. Psychopharmacology of Antipsychotics. London: Martin Dunitz Ltd; 1999:5.

  14. Seeman P, Tallerico T. Rapid release of antipsychotic drugs from dopamine D2 receptors: an explanation for low receptor occupancy and early clinical relapse upon withdrawal of clozapine or quetiapine. Am J Psychiatry. 1999;156(6):876-884.

  15. Richelson E, Souder T. Binding of antipsychotic drugs to human brain receptors: focus on newer generation compounds. Life Sciences. 2000;68:29-39.

  16. Kapur S, Zipursky R, Jones C, et al. A positron emission tomography study of quetiapine in schizophrenia: a preliminary finding of an antipsychotic effect with only transiently high dopamine D2 receptor occupancy. Arch Gen Psychiatry. 2000;57:553-559.

  17. De Nayer A, Martin Jones A, Whiteford JL, Altman CA. Switching to quetiapine improves CGI and PANSS scores in patients with schizophrenia. Poster presented at: CINP XXIIIrd Congress; June 23-27, 2002; Montreal, Canada. Poster Number: P.2.W.020.

  18. Meltzer HY, McGurk SR. The effects of clozapine, risperidone, and olanzapine on cognitive function in schizophrenia. Schizophr Bull. 1999;25:233-255.

  19. Velligan DI, Newcomer J, Pultz J, et al. Does cognitive function improve with quetiapine in comparison to haloperidol? Schizophr Res. 2002;53(3):239-248.

  20. Society for Neuroscience. Brain briefings: the prefrontal cortex and schizophrenia. Summer 1995.

  21. Tatsumi M, Jansen K, Blakely RD, Richelson E. Pharmacological profile of neuroleptics at human monoamine transporters. Eur J Pharmacol. 1999;368:277-283.

  22. Newman-Tancredi A, Verriele L, Touzard M, Millan MJ. Efficacy of antipsychotic agents at human 5-HT(1A) receptors determined by [3H]WAY100,635 binding affinity ratios: relationship to efficacy for G-protein activation. Eur J Pharmacol. 2001;428:177-184.
  23. Nutt, DJ. Putting the “A” in atypical: does alpha-2 adrenoceptor antagonism account for the therapeutic advantage of new antipsychotics? J Psychopharmacol. 1994;8:193-195.
  24. Freedman R. Nicotinic receptors and the genetics of schizophrenia and bipolar disorder. Program and abstracts of: American Psychiatric Association 155th Annual Meeting; May 18-23, 2002; Philadelphia, Pa.
  25. Tamminga CA. Glutamatergic transmission in schizophrenia. Program and abstracts of: American Psychiatric Association 155th Annual Meeting; May 18-23, 2002; Philadelphia, Pa.

  26. Araki H, Suemaru K, Gomita Y. Neuronal nicotinic receptor and psychiatric disorders: functional and behavioral effects of nicotine. Jpn J Pharmacol. 2002;88:133-138.

  27. Allison DB, Mentore JL, Heo M, et al. Antipsychotic-induced weight gain: a comprehensive research synthesis. Am J Psychiatry. 1999;156:1686-1696.

  28. Brecher M, Rak IW, Melvin K, et al. The long-term effect of quetiapine (Seroquel™) monotherapy on weight in patients with schizophrenia. Int J Psychiatry Clin Pract. 2000;4:287-291.

  29. Hägg S, Joelson L, Mjörndal T, et al. Prevalence of diabetes and impaired glucose tolerance in patients treated with clozapine compared with patients treated with conventional depot neuroleptic medications. J Clin Psychiatry. 1998;59:294-299.

  30. Mir S, Taylor D. Atypical antipsychotics and hyperglycaemia. Int Clin Psychopharmacol. 2001;16:63-73.

  31. Newcomer JW, Henderson DC, Lebovitz HE, et al. Metabolic disturbances associated with antipsychotic use. J Clin Psychiatry. (Audiograph Series) 2001;4:1-24.

  32. Nyberg S, Eriksson B, Oxenstierna G, et al. Suggested minimal effective dose of risperidone based on PET-measured D2 and 5-HT2A receptor occupancy in schizophrenic patients. Am J Psychiatry. 1999;156:869-875.
  33. Duggan L, Fenton M, Dardness RM, et al. Olanzapine for schizophrenia (Cochrane Review). In: The Cochrane Library, Issue 3, 2002. Available at: http://www.update-software.com/abstracts/ab001359.htm. Accessed September 9, 2002.

  34. Okubo Y, Suhara T. Receptor occupancy and antipsychotic drug action measured by PET and SPECT. Seishin Shinkeigaku Zasshi. 2001;103:329-340.
  35. Lieberman JA. Mechanism of action as predictor for clinical utility: lesson from schizophrenia research. Program and abstracts of: American Psychiatric Association 155th Annual Meeting; May 18-23, 2002; Philadelphia, Pa.

  36. Centorrino F, Price BH, Tuttle M, et al. EEG abnormalities during treatment with typical and atypical antipsychotics. Am J Psychiatry. 2002;159:109-115.
  37. Nyberg S, Chou YH, Halldin C. Saturation of striatal D2 dopamine receptors by clozapine. Int J Neuropsychopharmacol. 2002;5:11-16.

  38. Suhara T, Okauchi T, Sudo Y, et al. Clozapine can induce high dopamine D(2) receptor occupancy in vivo. Psychopharmacology (Berl). 2002;160:107-112.

  39. Kane JM. The new antipsychotics. J Prac Psych Behav Hlth. November,1997:343­354.

  40. Kennedy E, Song F, Hunter R, et al. Risperidone versus typical antipsychotic medication for schizophrenia (Cochrane Review). Cochrane Database Syst Review 2000;(2):CD000440.
  41. Gilbody SM, Bagnall AM, Duggan L, Tuunainen A. Risperidone versus other atypical antipsychotic medication for schizophrenia (Cochrane Review). In: The Cochrane Library, Issue 3, 2002. Oxford: Update Software. Available at: http://www.update-software.com/abstracts/ab002306.htm. Accessed Septermer 9, 2002.
  42. Marder SR, Davis JM, Chouinard G. The effects of risperidone on the five dimensions of schizophrenia derived by factor analysis: combined results of the North American trials. J Clin Psychiatry. 1997; 58:538-546.

  43. Csernansky JG, Mahmoud R, Brenner R. The Risperidone-USA-79 Study Group: a comparison of risperidone and haloperidol for the prevention of relapse in patients with schizophrenia. J Appl Physiol. 2001;91:755-761.

  44. Conley RR, Mahmoud R. A randomized double-blind study of risperidone and olanzapine in the treatment of schizophrenia or schizoaffective disorder. Am J Psychiatry. 2001;158:765-774.
  45. Tran PV, Hamilton SH, Kuntz AJ, et al. Double-blind comparison of olanzapine versus risperidone in the treatment of schizophrenia and other psychotic disorders. J Clin Psychopharmacol. 1997;17:407-418.

  46. Ho BC, Miller D, Nopoulos P, Anreasen NC. A comparative effectiveness study of risperidone and olanzapine in the treatment of schizophrenia. J Clin Psychiatry. 1999;60:658-663.

  47. Tollefson GD, Beasley CM Jr, Tran PV, et al. Olanzapine versus haloperidol in the treatment of schizophrenia and schizoaffective and schizophreniform disorders: results of an international collaborative trial. Am J Psychiatry. 1997;154:457-465.

  48. Stahl SM. Psychopharmacology of Antipsychotics. London: Martin Dunitz Ltd; 1999:101.

  49. Gefvert O, Lundberg T, Wieselgren IM, et al. D(2) and 5HT(2A) receptor occupancy of different doses of quetiapine in schizophrenia: a PET study. Eur Neuropsychopharmacol. 2001;11:105-110.

  50. Bagnall AM, Lewis RA, Leitner ML. Ziprasidone for schizophrenia and severe mental illness (Cochrane Review). In: The Cochrane Library, Issue 4. Avaliable at: http://www.update-software.com/abstracts/ab001945.htm. Accessed September 30, 2002.

  51. Weiden PJ. Ziprasidone: a new atypical antipsychotic. J Psychiatric Prac. 2001;7(2):145-154.

  52. Koro CE, Fedder DO, L'Italien GJ, et al. Assessment of independent effect of olanzapine and risperidone on risk of diabetes among patients with schizophrenia: population based nested case-control study. BMJ. 2002;325(7358):243.

 

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