Evolving Therapies for Advanced or Metastatic Hormone Receptor Positive (HR+) Breast Cancer: How Safety Profiles of CDK4/6 Inhibitors Affect Choice of First-Line Therapy – Case 1
Provided by The University of Tennessee College of Pharmacy, in cooperation with ASiM.
Supported by an educational grant from Pfizer Inc.
The mainstay of therapy for patients with HR-positive (HR+) breast cancer, at all stages of disease, is hormonal therapy, which has proven to be clinically beneficial for those with tumor regression and favorable toxicity profiles for metastatic and nonmetastatic HR+ breast cancer. However, endocrine therapy resistance limits the utility of these agents. About half of patients with HR+ metastatic breast cancer (MBC) gain a clinical benefit from endocrine therapy. The majority of patients with HR+ MBC that initially respond to endocrine therapy recurs in a therapy-resistant form despite continued estrogen receptor expression. Three CDK4/6 inhibitors are available for patients with HR+ advanced or MBC: abemaciclib, ribociclib, and palbociclib. However, the exact role and sequencing of CDK4/6 inhibitors for this patient population is still being debated. This activity will contrast efficacy, safety, and drug interaction differences between CDK4/6 inhibitors, in order to guide the choice of agent for the treatment of patients with HR+ MBC.
The goal of this activity is to improve clinicians' understanding of the rationale behind the selection of CDK4/6 inhibitors for first-line therapy of patients with HR+, HER2-negative (HER2-) MBC. Participants will be able to differentiate patients that may experience lower treatment toxicity based on the their comorbidity profile and known side effects of the CDK4/6 inhibitors.
This activity has been designed to meet the needs of oncology, health system, managed care, specialty pharmacists and other pharmacists who manage patients receiving systemic therapy for HR+ breast cancer. No prerequisites required.
The University of Tennessee College of Pharmacy takes responsibility for the content, quality, and scientific integrity of this CPE activity. At the conclusion of this activity, the participant should be able to:
- FORMULATE recommendations for first-line treatment of HR+/HER2-neg metastatic breast cancer (MBC) with CDK 4/6 inhibitors.
- COMPARE the safety profiles of the three FDA approved CDK 4/6 inhibitors.
CREDIT DESIGNATION STATEMENT
The University of Tennessee College of Pharmacy is accredited by the Accreditation Council for Pharmacy Education (ACPE) as a provider of continuing pharmacy education. Successful completion of this knowledge-based activity will provide a statement for .5 contact hour of credit (0.5 CEU) and will be available at the completion of the activity. Successfully completing the activity and receiving credit includes: 1) reading the learning objectives and faculty disclosures; 2) studying the educational activity; 3) evaluating the activity; and, 4) completing the self-assessment instrument with a score of at least 70%. UAN: 0064-0000-18-203-H01-P. CE credit will be submitted to the NABP CPE Monitor within 30 days. It is recommended that you check your NABP CPE Monitor e-profile database 30 days after the completion of any CE activity to ensure that your credits are posted.
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Type of Activity: Knowledge
Fee Information: There is no fee for this educational activity.
Estimated time to complete activity: 30 minutes
October 31, 2018
October 31, 2019
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FACULTY AUTHOR AND CHAIR
Larry W. Buie, PharmD, BCOP, FASHP
Adult Residency Program Director/ Manager, Clinical Pharmacy Services
Memorial Sloan Kettering Cancer Center
New York, New York
Dr Buie reports serving as a consultant for Heron Therapeutics Inc and Pfizer Inc.
OFF-LABEL PRODUCT DISCUSSION
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TABLE OF CONTENTS
Evolving Therapies for Advanced or Metastatic Hormone Receptor Positive (HR+) Breast Cancer:
How Safety Profiles of CDK4/6 Inhibitors Affect Choice of First-Line Therapy
Larry W. Buie, PharmD, BCOP, FASHP
Postassessment and Evaluation
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