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Bruton's Tyrosine Kinase Inhibitors for Mature B-Cell Neoplasms: Focus on Efficacy and Safety of Available Agents

This educational activity is sponsored by Postgraduate Healthcare Education, LLC (PHE) and supported by an educational grant from AstraZeneca Pharmaceuticals LP.


Christopher Fausel, PharmD, MHA, BCOP (Chair)
Clinical Manager, Oncology Pharmacy
Indiana University Health
Indianapolis, IN

Larry W. Buie, PharmD, BCOP, FASHP
Clinical Pharmacy Manager and PGY2 Oncology Residency Program Director
Memorial Sloan Kettering Cancer Center
New York, NY

R. Donald Harvey III, PharmD, BCOP, FCCP, FHOPA
Professor, Department of Hematology and Medical Oncology and
Department of Pharmacology and Chemical Biology
Emory University School of Medicine
Director, Phase l Clinical Trials Section
Atlanta, GA

Laura K. Whited, PharmD, BCOP
Clinical Pharmacy Specialist-Stem Cell Transplantation & Cellular Therapy
University of Texas MD Anderson Cancer Center
Houston, TX


Drs. Fausel and Whited have no relevant affiliations or financial relationships with a commercial interest to disclose.

Dr. Buie has disclosed that he does/has served as a consultant for Amgen, Pfizer and Jazz Pharmaceuticals.

Dr. Harvey has disclosed that he has served as a consultant for BMS, Genentech and Takeda; and that his institution has received research funding from Abbvie, Amgen, Arqule, Astra Zeneca, Boston Biomedical, Bristol-Myers Squibb, Calithera, Celgene, Cleave, Corvus, Eli Lilly, Five Prime Therapeutics, GenMab, Halozyme, Ignyta, Incyte, Merck, Nektar,  Pfizer, Regeneron, Rgenix, Sanofi, Syndax, Takeda,Tesaro, Vertex and Xencor that supports his salary. The clinical reviewer, Megan May, PharmD, BCOP, has no actual or potential conflict of interest in relation to this program.

Susanne Batesko, RN, BSN, Robin Soboti, R.Ph, and Susan R. Grady, MSN, RN-BC, as well as the planners, managers, and other individuals, not previously disclosed, who are in a position to control the content of Postgraduate Healthcare Education (PHE) continuing education (CE) activities hereby state that they have no relevant conflicts of interest and no financial relationships or relationships to products or devices during the past 12 months to disclose in relation to this activity. PHE is committed to providing participants with a quality learning experience and to improve clinical outcomes without promoting the financial interests of a proprietary business.


acpePostgraduate Healthcare Education, LLC is accredited by the Accreditation Council for Pharmacy Education as a provider of continuing pharmacy education.
UAN: 0430-0000-19-091-H01-P
Credits: 1.5 hour (0.15 ceu)

Type of Activity: Application 
Media: Webinar

Fee Information: There is no fee for this educational activity.
Estimated time to complete activity: 90 minutes


October 28, 2019


October 28, 2020


This accredited activity has been designed for oncology, managed care and specialty pharmacists.


During the period October 28, 2019 to October 28, 2020 participants must 1) read the learning objectives and faculty disclosures; 2) view the educational activity; and 3) complete the posttest and evaluation form directly after the activity within a maximum of 60 days of participating in the activity. To answer the questions, click on your selected choice for each answer then proceed to the next question. Once completed, click on the Grade Exam button at the bottom of the page. Your posttest will automatically be graded. If you successfully complete the posttest (score of 70% or higher), your statement of participation will be made available immediately. Click on the View Statement of Participation link and print the statement for your records. If you receive a score lower than 70%, you will receive a message notifying you that you did not pass the posttest. You will have 2 opportunities to pass the posttest. To receive Credit, you must provide your date of birth and NABP number. All Credit information will be uploaded into CPE monitor within 30 days.


The goal of this educational activity is to inform and educate oncology, managed care and specialty pharmacists on differences in pharmacology, efficacy, and safety of BTK inhibitors and roles that pharmacists can play to drive appropriate access to and use of BTK inhibitors to optimize outcomes for patients with mature B-cell neoplasms.


Upon completion of this program, participants should be better able to:

  • Compare and contrast the BTK inhibitors, including their pharmacological differences
  • Discuss key published clinical trials, ongoing clinical trials, and guideline recommendations for BTK inhibitors in MCL and CLL
  • Design a treatment plan involving an appropriate BTK inhibitor and corresponding safety considerations
  • Formulate effective strategies for ensuring the proper selection and use of BTK inhibitors in the care of individual patients and patient populations

Presentation Handout(s)

Click below here to Download:


Please ensure the computer system you plan to use meets the following minimum requirements:

  • Operating System: Windows 98 or higher & Macintosh 2.2 or higher
  • Internet Browser (Mac &/Windows): Internet Explorer 6.0 or higher, Google Chrome, Safari 5.0.6 or higher, Firefox 3.0.3 or higher & Opera 5 or higher
  • Broadband Internet connection: Cable, High-speed DSL & any other medium that is internet accessible
  • Monitor Screen Resolution: 320 x 480 or higher
  • Media Viewing Requirements: Adobe Reader, Microsoft PowerPoint, Flash Player & HTML5

Disclosure of Unlabeled Use and Disclaimer

The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of Postgraduate Healthcare Education, LLC or AstraZeneca Pharmaceutical LP. Participants have an implied responsibility to use the newly acquired information to enhance patient outcomes and their own professional development. The information presented in this activity is not meant to serve as a guideline for patient management. Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this activity should not be used by clinicians without evaluation of their patients' conditions, and possible contraindications on dangers in use, (review of any applicable manufacturer's product information) and comparison with recommendations of other authorities.

The author, sponsor, and publisher of this continuing education activity have made all reasonable efforts to ensure that all information contained herein is accurate in accordance with the latest available scientific knowledge at the time of acceptance for publication. However, because information regarding drugs (their administration, dosages, contraindications, adverse reactions, interactions, special warnings, precautions, etc.) is subject to constant change, the reader is advised to check the manufacturer's package insert for information concerning recommended dosages and potential problems and cautions prior to dispensing or administering the drug. Special precautions should be taken when a drug is new, or highly toxic, or is unfamiliar to the dispenser or administrant. This educational activity may contain discussion of published and/or investigational uses of agents that are not approved by the U.S. Food and Drug Administration (FDA). Neither the publisher nor sponsor promotes the use of any agent outside of approved labeling. Statements made in this monograph have not been evaluated by the FDA. Nutritional products discussed are not intended for the diagnosis, treatment, cure, or prevention of any disease.