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Practical Solutions to Prevent and Prepare for Severe Hypoglycemia

Sponsored by Purdue University College of Pharmacy, in partnership with the Academy for Continued Healthcare Learning (ACHL).

This activity is supported by an educational grant from Lilly.


Episodes of hypoglycemia, including those that are severe, still occur despite new pharmacotherapies and the increased use of continuous glucose monitoring. Do you know which of your patients are at risk? Are they prepared with an active glucagon prescription? This activity helps you identify at risk patients and ensure they are prepared with access to glucagon. Included with the education are tools to educate patients and establish processes to improve hypoglycemia recognition and success with glucagon administration.


Davida F. Kruger, MSN, APN-BC, BC-ADM
Certified Nurse Practitioner
Henry Ford Health System
Division of Endocrinology, Diabetes, Bone and Mineral Disease
Detroit, MI

Anne Louise Peters, MD
Professor of Clinical Medicine
Keck School of Medicine of USC
Los Angeles, CA

Release Date: September 9, 2022
Expiration Date: September 9, 2023


The content for this activity was developed independently of the commercial supporter. All materials are included with permission. The opinions expressed are those of the faculty and are not to be construed as those of the publisher or grantor.

This educational activity was planned and produced in accordance with the ACCME and ACPE Standards for Integrity and Independence in Accredited Continuing Education. Recommendations involving clinical medicine in a continuing medical education (CME/CE) activity must be based on evidence that is accepted within the profession of medicine as adequate justification for their indications and contraindications in the care of patients. All scientific research referred to, reported, or used in CME/CE in support or justification of a patient care recommendation must conform to the generally accepted standards of experimental design, data collection, and analysis.

This CME/CE activity might describe the off-label, investigational, or experimental use of medications and/or devices that may exceed their FDA-approved labeling. Physicians should consult the current manufacturers’ prescribing information for these products. Purdue University College of Pharmacy requires the speaker to disclose that a product is not labeled for the use under discussion.

Target Audience

This activity is intended for the multispecialty clinical team across physicians, nurses, nurse practitioners, physician assistants, pharmacists, and other healthcare providers who manage patients with diabetes and play a role in helping patients prevent and/or prepare for a severe hypoglycemic event.

Activity Purpose

Hypoglycemia is a common complication of treatment that negatively impacts quality of life and elicits fears in patients with diabetes. Severe episodes, in which the person requires assistance from others, can have negative health consequences such as increased mortality. Identifying patients who are at risk for severe episodes and making sure they and their caregivers are prepared can improve outcomes. Yet, many patients are not prepared, and guideline-recommended glucagon is under prescribed in eligible patients.

Learning Objectives

Upon completion of this activity, participants will be able to:

  • Identify patient-level predictors of severe hypoglycemia and related morbidity
  • Discuss the barriers to recognizing and treating severe hypoglycemia
  • Utilize strategies to increase and optimize the prevention and preparedness for severe hypoglycemia
  • Implement patient education approaches to improve success rates for glucagon administration for severe hypoglycemic events

Method of Participation

This activity will take approximately 60 minutes to complete. To receive credit, participants are required to complete the pretest, view the online activity and complete the posttest and evaluation. To receive credit, 75% must be achieved on the posttest. A certificate will be immediately available. There is no fee to participate in the activity or for the generation of the certificate.

For questions, contact Laurie Novoryta at Lnovoryta@achlcme.org. 

CPE credit will be submitted to CPE Monitor® on the first day of each month.

Continuing Pharmacy Education Statement


Purdue University College of Pharmacy is accredited by the Accreditation Council for Pharmacy Education as a provider of continuing pharmacy education. This is a knowledge based, continuing education activity of Purdue University, an equal access/equal opportunity institution.

This activity has been approved for 1.0 contact hour.

ACPE Universal Activity Number: 0018-9999-22-023-H01-P
Activity Type(s): Application
Release Date: September 9, 2022
Expiration Date: September 9, 2023

Faculty Disclosures

To ensure compliance with the ACCME Standards for Integrity and Independence in Accredited Continuing Education, Purdue University requires that all individuals in a position to control the content of an educational activity disclose all financial relationships with ineligible companies whose primary business is producing, marketing, selling, re-selling, or distributing healthcare products used by or on patients. All relevant conflicts of interest identified are thoroughly assessed by Purdue University to ensure fair balance, scientific rigor, and accepted patient care recommendations of the educational activity.

The following financial relationships have been provided:
Davida F. Kruger, MSN, APN-BC,BC-ADM
Consultant: Abbott, Cequr, Modular Medical, Novo Nordisk, Sanofi
Research Support: Abbott, Beta Bionics, Dexcom, Novo Nordisk,
Speaker: Cequr, Dexcom, Lilly, Novo Nordisk, Sanofi, Xeris
Stock: Pendulum

Anne Louise Peters, MD
Advisory Board: Abbott Diabetes Care, Astra Zeneca, Eli Lilly, Novo Nordisk, Zealand
Research Support: Abbott Diabetes Care, Dexcom, Insulet
Stock/Stock Options: Omada Health, Teladoc

Discussion of Off-Label, Investigational, or Experimental Drug/Device Use: None

All relevant conflicts of interest have been mitigated prior to the start of the activity .

Staff and Reviewer Disclosures
None of the planners, reviewers, ACHL, and Purdue University College of Pharmacy staff have relevant financial relationship(s) with ineligible companies to disclose unless listed below.


Didactic Module
Recognizing Hypoglycemia
Hypoglycemia Fear and Unawareness
Clinical Surveillance and Management

Case-based Discussion
Case 1: Recently diagnosed patient with type 2 diabetes Case 2: Patient with 22-year history of type 2 diabetes

Hardware and Software Requirements

Please ensure the computer system you plan to use meets the following minimum requirements:

  • Operating System: Windows 98 or higher & Macintosh 2.2 or higher
  • Internet Browser (Mac & Windows): Internet Explorer 6.0 or higher, Google Chrome, Safari 5.0.6 or higher, Firefox 3.0.3 or higher, & Opera 5 or higher
  • Broadband Internet connection: Cable, High-speed DSL & any other medium that is internet accessible
  • Peripherals: Computer speakers or headphones
  • Monitor Screen Resolution: 320 x 480 or higher
  • Media Viewing Requirements: Adobe Reader, Microsoft PowerPoint, Flash Player & HTML5