1. What is the maximum recommended daily dose of acetaminophen for an adult?
A. 325 mg
B. 1300 mg
C. 3000 mg
D. 7500 mg
2. What is the concentration of most commonly available infants' and children's oral liquid formulations of acetaminophen?
A. 10 mg/mL
B. 160 mg/5 mL
C. 200 µg/mL
D. 10,000 IU/L
3. Which of the following single doses of acetaminophen is considered a toxic dose for an adolescent or adult?
A. 3 g
B. 200 mg/kg
C. 1000 mg
D. 7.5 g
4. According to guidelines established by the U.S. Food and Drug Administration, what is the maximum amount of acetaminophen that should be contained in each dosage unit of a combination prescription product?
A. 325 mg
B. 650 mg
C. 1300 mg
D. 4000 mg
5. During what stage of acetaminophen-induced hepatotoxicity does maximal liver injury occur?
A. Stage I
B. Stage II
C. Stage III
D. Stage IV
6. Which of the following is NOT a contraindication to administration of activated charcoal for acetaminophen (APAP) overdose?
A. An unprotected airway
B. A compromised gastrointestinal tract
C. Ingestion of an extended-release APAP product
D. All of the above are contraindications to activated charcoal therapy
7. What is one way that acetylcysteine protects against acetaminophen (APAP)-induced hepatotoxicity?
A. It depletes glutathione stores
B. It forms a reactive intermediate, N-acetyl-p-benzoquinoneimine (NAPQI)
C. It increases oxidative stress
D. It reduces NAPQI to APAP
8. Which of the following acetaminophen (APAP) levels indicates that acetylcysteine treatment is warranted after an acute overdose of APAP?
A. 25 µg/mL 4 hours after ingestion
B. 150 µg/mL 4 hours after ingestion
C. 200 µg/mL 2 hours after ingestion
D. 1000 µg/mL 1 hour after ingestion
9. In what situation is application of the Rumack-Matthew nomogram appropriate?
A. A patient ingested a single, toxic dose of single-ingredient, immediate-release acetaminophen (APAP) 8 hours ago
B. A patient has ingested 4000 mg of extended-release APAP daily for 7 days
C. A patient has ingested 2 APAP-containing combination products for pain for 14 days
D. A patient received a 10-fold overdose of intravenous APAP 36 hours ago
10. Pharmacists should do which of the following to ensure the safe, effective use of acetaminophen (APAP)?
A. Report medication errors to adverse drug event reporting systems or poison control centers to mitigate future errors
B. Verify the indication for all APAP dispensed
C. Educate parents and caregivers on the use of measuring devices for infants' and children's APAP formulations
D. All of the above
Evaluation Questions
11. To what extent did the program meet objective #1?
A. Excellent
B. Very Good
C. Good
D. Fair
E. Poor
12. To what extent did the program meet objective #2?
A. Excellent
B. Very Good
C. Good
D. Fair
E. Poor
13. To what extent did the program meet objective #3?
A. Excellent
B. Very Good
C. Good
D. Fair
E. Poor
14. To what extent did the program meet objective #4?
A. Excellent
B. Very Good
C. Good
D. Fair
E. Poor
15. Rate the effectiveness of how well the program related to your educational needs:
A. Excellent
B. Very Good
C. Good
D. Fair
E. Poor
16. Rate how well the active learning strategies (questions, cases, discussions) were appropriate and effective learning tools:
A. Excellent
B. Very Good
C. Good
D. Fair
E. Poor
17. Rate the quality of the faculty:
A. Excellent
B. Very Good
C. Good
D. Fair
E. Poor
18. Rate the effectiveness and the overall usefulness of the material presented:
A. Excellent
B. Very Good
C. Good
D. Fair
E. Poor
19. Rate the appropriateness of the examination for this activity:
A. Excellent
B. Very Good
C. Good
D. Fair
E. Poor
20. Rate the effectiveness of how well the activity related to your practice needs:
A. Excellent
B. Very Good
C. Good
D. Fair
E. Poor
21. Rate the effectiveness of how well the activity will help you improve patient care:
A. Excellent
B. Very Good
C. Good
D. Fair
E. Poor
22. Will the information presented cause you to change your practice?
A. Yes
B. No
23. Are you committed to making these changes?
A. Yes
B. No
24. As a result of this activity, did you learn something new?
A. Yes
B. No
25. What is your practice setting or area of practice?
A. Community Pharmacy/Independent
B. Community Pharmacy/Chain
C. Hospital/Health Systems
D. Administrative/Pharmacy Director
E. Critical Care Pharmacy
F. Long-term Care
G. Managed Care/PBM
H. Oncology
I. Specialty Pharmacy
J. Industry/Manufacturing
26. How many years have you been in practice?
A. <5
B. 5 – 10
C. 11 – 20
D. >20