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1. Which of the following types of von Willebrand disease is an autosomal recessive disorder caused by null alleles that results in complete absence of von Willebrand factor?

A. Acquired B. Type 1 C. Type 2A D. Type 3

2. Which of the following types of von Willebrand disease is a result of an immune-mediated reduction in von Willebrand factor?

A. Acquired B. Type 1 C. Type 2B D. Type 3

3. Which of the following types of von Willebrand disease is the most common?

A. Acquired B. Type 1 C. Type 2M D. Type 3

4. Which of the following underlying conditions is most commonly associated with acquired von Willebrand disease?

A. Cardiovascular disease B. Immunologic diseases C. Lymphoproliferative disorders D. Myeloproliferative disorders

5. Bleeding history is important in the clinical diagnosis of von Willebrand disease because it:

A. Is highly specific B. Is highly sensitive C. Distinguishes between acquired and inherited forms D. Negates the need for a bleeding score

6. If the first-level laboratory test result of von Willebrand factor is less than 5 IU/dL and the second-level laboratory test of von Willebrand factor propeptide is also less than 5 IU/dL, which of the following types of von Willebrand disease is present?

A. Acquired B. Type 1 C. Type 2N D. Type 3

7. Which of the following treatments would benefit a patient with acquired von Willebrand disease and an underlying condition of monoclonal gammopathy of unknown significance?

A. Desmopressin 300 mcg puff twice daily x 2 days B. Immunoglobulin 1 g/kg daily x 2 days C. Recombinant factor VIII 90 mcg/kg x 1 dose D. Tranexamic acid 15 mg/kg every 8 h x 2 days

8. Which of the following treatments is most appropriate for a young woman (> 50 kg) with severe menorrhagia?

A. Aminocaproic acid 10 mg/kg/day until bleeding subsides B. Desmopressin 0.1% nasal spray 1 spray/day until bleeding subsides C. Recombinant factor VIII 90 mcg/kg/day until bleeding subsides D. Tranexamic acid 15 mg/kg 3 times daily until bleeding subsides

9. Recombinant von Willebrand factor is indicated for which of the following conditions?

A. Control of bleeding and perioperative management of bleeding in children and adults with von Willebrand disease B. Surgical and invasive procedures in adults with von Willebrand disease (VWD) C. Treatment of spontaneous and trauma-induced bleeding episodes in adult and pediatric patients with VWD D. Treatment and control of bleeding episodes in adults with VWD

10. Which of the following potential side effects is NOT associated with recombinant von Willebrand factor?

A. Hypersensitivity reactions B. Neutralizing antibodies C. Thromboembolism D. Viral transmission

Maintenance is scheduled for 8/7/2023 7:00 AM EST - 8:00 AM EST.

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1. Which of the following types of von Willebrand disease is an autosomal recessive disorder caused by null alleles that results in complete absence of von Willebrand factor?

2. Which of the following types of von Willebrand disease is a result of an immune-mediated reduction in von Willebrand factor?

3. Which of the following types of von Willebrand disease is the most common?

4. Which of the following underlying conditions is most commonly associated with acquired von Willebrand disease?

5. Bleeding history is important in the clinical diagnosis of von Willebrand disease because it:

6. If the first-level laboratory test result of von Willebrand factor is less than 5 IU/dL and the second-level laboratory test of von Willebrand factor propeptide is also less than 5 IU/dL, which of the following types of von Willebrand disease is present?

7. Which of the following treatments would benefit a patient with acquired von Willebrand disease and an underlying condition of monoclonal gammopathy of unknown significance?

8. Which of the following treatments is most appropriate for a young woman (> 50 kg) with severe menorrhagia?

9. Recombinant von Willebrand factor is indicated for which of the following conditions?

10. Which of the following potential side effects is NOT associated with recombinant von Willebrand factor?

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Maintenance is scheduled for 8/7/2023 7:00 AM EST - 8:00 AM EST.

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1. Which of the following types of von Willebrand disease is an autosomal recessive disorder caused by null alleles that results in complete absence of von Willebrand factor?

2. Which of the following types of von Willebrand disease is a result of an immune-mediated reduction in von Willebrand factor?

3. Which of the following types of von Willebrand disease is the most common?

4. Which of the following underlying conditions is most commonly associated with acquired von Willebrand disease?

5. Bleeding history is important in the clinical diagnosis of von Willebrand disease because it:

6. If the first-level laboratory test result of von Willebrand factor is less than 5 IU/dL and the second-level laboratory test of von Willebrand factor propeptide is also less than 5 IU/dL, which of the following types of von Willebrand disease is present?

7. Which of the following treatments would benefit a patient with acquired von Willebrand disease and an underlying condition of monoclonal gammopathy of unknown significance?

8. Which of the following treatments is most appropriate for a young woman (> 50 kg) with severe menorrhagia?

9. Recombinant von Willebrand factor is indicated for which of the following conditions?

10. Which of the following potential side effects is NOT associated with recombinant von Willebrand factor?

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