1. Which of the following investigational treatments for patients with major depressive disorder works as an opioid modulator?

2. SG is a 68-year-old woman with major depressive disorder and anxiety. She has already failed sertraline therapy and has been switched to citalopram. She has been taking citalopram for 4 weeks with her dose gradually increasing to 20 mg/day. According to her caregiver, she has not had any improvements in her symptoms and has also been displaying symptoms of cognitive dysfunction. Which of the following treatment strategies is MOST appropriate for SG?

3. Which of the following statements regarding vortioxetine is TRUE?

4. TRUE or FALSE: A medication class other than selective serotonin reuptake inhibitor (SSRI) may be preferentially beneficial for a patient experiencing cognitive symptoms or inattention.

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