1. Which of the following describes the correct mechanism of action of the fluoroquinolone antibiotics?
A. Inhibition of transpeptidation of peptidoglycan in cell wall biosynthesis
B. Inhibition of DNA replication through inhibition of DNA gyrase and topoisomerase IV
C. Inhibition of protein synthesis by binding to the 50S ribosomal subunit
D. Inhibition of 14α-demethylase, which prevents the conversion of lanosterol to ergosterol
2. Which of the following are included in the boxed warnings for all fluoroquinolone antibiotics?
A. Tendonitis and tendon rupture
B. Peripheral neuropathy and central nervous system effects
C. Exacerbation of myasthenia gravis
D. All of the above
3. Delafloxacin has activity against which of the following organisms?
A. Pseudomonas aeruginosa
B. Methicillin-resistant Staphylococcus aureus
C. Escherichia coli
D. All of the above
4. Which of the following adverse effects is NOT expected with delafloxacin therapy?
A. Prolongation of the QTc interval
B. Photosensitivity
C. Gastrointestinal upset including nausea, diarrhea, and vomiting
D. A and B
5. Which of the following medications has activity against methicillin-resistant Staphylococcus aureus and is available in an oral formulation?
A. Dalbavancin
B. Delafloxacin
C. Ceftaroline
D. All of the above
6. Which of the following oral antimicrobial agents are recommended by the Infectious Diseases Society of America guidelines for the treatment of purulent cellulitis when the suspected causative microorganism is methicillin-resistant Staphylococcus aureus ?
A. Minocycline
B. Sulfamethoxazole-trimethoprim
C. Clindamycin
D. All of the above
7. HB is a 44-year-old man who has not responded to treatment with doxycycline or cephalexin for a skin infection in the axilla following surgery. He has experienced a rash from sulfamethoxazole-trimethoprim in the past. He is colonized with methicillin-resistant Staphylococcus aureus . What would be the most appropriate oral therapy for the treatment of this patient?
A. Minocycline
B. Levofloxacin
C. Delafloxacin
D. Cefazolin
8. When acute bacterial skin and skin structure infections have a culturable source, such as a drainable abscess (also referred to as a “purulent infection”), which of the following organisms are most frequently identified as the causative agent of infection?
A. Neisseria gonorrhea
B. Acinetobacter spp.
C. Streptococcus hominis
D. Staphylococcus aureus
9. Which of the following organisms is considered responsible for the majority of non-purulent acute bacterial skin and skin structure infections?
A. Pseudomonas spp.
B. Beta-hemolytic streptococci
C. Escherichia coli
D. Cryptococcus neoformans
10. Resistance to the fluoroquinolone antibiotics occurs by what mechanism?
A. Mutations in parC or gyrA resulting in target site alterations
B. Methylation of the D-ala terminus resulting in altered binding to the cell wall
C. Inactivation by metallofluoroquinolases
D. None of the above
Evaluation Questions
11. To what extent did the program meet objective #1?
A. Excellent
B. Very Good
C. Good
D. Fair
E. Poor
12. To what extent did the program meet objective #2?
A. Excellent
B. Very Good
C. Good
D. Fair
E. Poor
13. To what extent did the program meet objective #3?
A. Excellent
B. Very Good
C. Good
D. Fair
E. Poor
14. To what extent did the program meet objective #4?
A. Excellent
B. Very Good
C. Good
D. Fair
E. Poor
15. To what extent did the program meet objective #5?
A. Excellent
B. Very Good
C. Good
D. Fair
E. Poor
16. Rate the effectiveness of how well the program related to your educational needs:
A. Excellent
B. Very Good
C. Good
D. Fair
E. Poor
17. Rate how well the active learning strategies (questions, cases, discussions) were appropriate and effective learning tools:
A. Excellent
B. Very Good
C. Good
D. Fair
E. Poor
18. Rate the quality of the faculty:
A. Excellent
B. Very Good
C. Good
D. Fair
E. Poor
19. Rate the effectiveness and the overall usefulness of the material presented:
A. Excellent
B. Very Good
C. Good
D. Fair
E. Poor
20. Rate the appropriateness of the examination for this activity:
A. Excellent
B. Very Good
C. Good
D. Fair
E. Poor
21. Rate the effectiveness of how well the activity related to your practice needs:
A. Excellent
B. Very Good
C. Good
D. Fair
E. Poor
22. Rate the effectiveness of how well the activity will help you improve patient care:
A. Excellent
B. Very Good
C. Good
D. Fair
E. Poor
23. Will the information presented cause you to change your practice?
A. Yes
B. No
24. Are you committed to making these changes?
A. Yes
B. No
25. As a result of this activity, did you learn something new?
A. Yes
B. No
26. What is your practice setting or area of practice?
A. Community Pharmacy/Independent
B. Community Pharmacy/Chain
C. Hospital/Health Systems
D. Administrative/Pharmacy Director
E. Critical Care Pharmacy
F. Long-term Care
G. Managed Care/PBM
H. Oncology
I. Specialty Pharmacy
J. Industry/Manufacturing
27. How many years have you been in practice?
A. <5
B. 5 – 10
C. 11 – 20
D. >20
E. >20
