1. Increased levels of FGF23, the underlying defect in patients with X-linked hypophosphatemia, is associated with which of the following changes in renal function?

2. In addition to rickets and bone deformity, X-linked hypophosphatemia causes symptoms in what other organs and tissues of the body?

3. Which of the following statements best describes X-linked hypophosphatemia?

4. Medications containing which of the following ions can exacerbate X-linked hypophosphatemia through binding to phosphates?

5. Clinical symptoms of X-linked hypophosphatemia can be mistaken as which of the following conditions?

6. In children, treatment of X-linked hypophosphatemia generally begins with:

7. Following initiation of standard therapy for X-linked hypophosphatemia in children, which of the following symptoms would be expected to improve first?

8. In patients receiving standard therapy for X-linked hypophosphatemia, which of these actions shown is a correct response to the listed monitoring test result?

9. Based on clinical trials of children receiving burosumab for X-linked hypophosphatemia, improvements in rickets and bone healing should be expected within what timeframe?

10. JB is a 4-year-old girl diagnosed 2 years ago with X-linked hypophosphatemia. Despite adherence and some improvements in serum levels, she has not responded fully to standard therapy. A course of burosumab is appropriate provided which of the following is not present in JB?

Evaluation Questions

11. How confident are you in your decision to treat your patient JB above?

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