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1. Fluoroquinolones can develop drug resistance by which mechanism?

A. Efflux pumps B. Porin channel loss C. Ribosomal mutations D. Target site mutations

2. Porin channel loss is the resistance mechanism for which class of antibiotics?

A. Tetracyclines B. Aminoglycosides C. Beta-lactams including carbapenems D. Sulfonamides

3. Bacteria that develop resistance vie efflux pumps impact the use of which antibiotics?

A. Beta-lactams B. Beta-lactams, fluoroquinolones C. Beta-lactams, fluoroquinolones, aminoglycosides D. Beta-lactams, fluoroquinolones, aminoglycosides, tetracyclines

4. Which of the following are mutations in which cellular component create resistance to polymyxins?

A. Ion channels B. Lipopolysaccharide C. Membrane protein D. Ribosomes

5. Eravacycline would not be an appropriate option for patients with which type of infection?

A. Escherichia coli B. P. aeruginosa C. Klebsiella pneumoniae D. Acinetobacter

6. Ceftolozane/tazobactam is a useful treatment option for which type of MDR infection?

A. P. aeruginosa B. Klebsiella pneumoniae C. Acinetobacter D. All of the above

7. Which susceptibilities tests are options to request for a 75-year-old female, with a history of type 2 diabetes mellitus and renal transplant, who presents with fever, abdominal pain and jaundice? A month ago, she was hospitalized with kidney stones and underwent lithotripsy at which time she had an indwelling catheter placed temporarily and received a broad-spectrum cephalosporin.

A. Ceftazidime/avibactam B. Meropenem/vaborbactam and plazomicin C. Eravacycline D. All of the above

8. Plazomicin's spectrum of activity include which bacteria?

A. E. coli, K. pneumoniae, Proteus, Enterobacter species, Staphylococcus aureus B. P. aeruginosa, K, pneumoniae, Acinetobacter, Enterococcus C. E. coli, P. aeruginosa, Acinetobacter, Streptococcus D. Streptococcus, Stenotrophamonas maltophilia

9. Ceftazidime/avibactam is approved for which of the following indications?

A. cUTI B. cIAI C. cUTI, cIAI D. cUTI, cIAI, HAP.VAP

10. Which of the following interventions has been found LESS effective as part of an antimicrobial stewardship program?

A. Prospective auditing B. Educational materials C. Preauthorization D. All are effective

Maintenance is scheduled for 8/7/2023 7:00 AM EST - 8:00 AM EST.

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1. Fluoroquinolones can develop drug resistance by which mechanism?

2. Porin channel loss is the resistance mechanism for which class of antibiotics?

3. Bacteria that develop resistance vie efflux pumps impact the use of which antibiotics?

4. Which of the following are mutations in which cellular component create resistance to polymyxins?

5. Eravacycline would not be an appropriate option for patients with which type of infection?

6. Ceftolozane/tazobactam is a useful treatment option for which type of MDR infection?

8. Plazomicin's spectrum of activity include which bacteria?

9. Ceftazidime/avibactam is approved for which of the following indications?

10. Which of the following interventions has been found LESS effective as part of an antimicrobial stewardship program?

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Maintenance is scheduled for 8/7/2023 7:00 AM EST - 8:00 AM EST.

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1. Fluoroquinolones can develop drug resistance by which mechanism?

2. Porin channel loss is the resistance mechanism for which class of antibiotics?

3. Bacteria that develop resistance vie efflux pumps impact the use of which antibiotics?

4. Which of the following are mutations in which cellular component create resistance to polymyxins?

5. Eravacycline would not be an appropriate option for patients with which type of infection?

6. Ceftolozane/tazobactam is a useful treatment option for which type of MDR infection?

8. Plazomicin's spectrum of activity include which bacteria?

9. Ceftazidime/avibactam is approved for which of the following indications?

10. Which of the following interventions has been found LESS effective as part of an antimicrobial stewardship program?

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