A. Change the treatment from avelumab to pembrolizumab and continue the axitinib B. Change the treatment from avelumab to ipilimumab and continue the axitinib C. Hold therapy and start prednisone 0.5 mg/kg daily D. Start loperamide 2 mg every 2 hours and increase hydration; follow up at his regular visit in 2 days E. Unsure

A. Due to the timing, this is not likely due to the immunotherapy but to some physical strain B. Put ice on the knees and elevate them for 2 hours a day; add a non-steroidal anti-inflammatory drug as needed C. Take prednisone 0.5 mg/kg daily and consider a rheumatology consult D. Add acetaminophen, stop the nivolumab, and start pembrolizumab E. Unsure

A. Immunotherapy is no longer acceptable; once disease progression occurs, start sunitinib B. Since there has been a break in therapy, dual therapy with nivolumab and ipilimumab should be re-initiated for 2 cycles C. Nivolumab plus axitinib should be started D. Nivolumab monotherapy can be restarted without negative prognostic implications E. Unsure

A. Pembrolizumab plus axitinib B. Nivolumab plus ipilimumab C. Avelumab plus sunitinib D. Pazopanib E. Unsure

A. Re-initiate nivolumab monotherapy once the prednisone taper reaches 10 mg per day (approximately 4 weeks) B. Re-initiate nivolumab and ipilimumab once the prednisone taper reaches 10 mg per day (approximately 3 weeks) C. Discontinue the immunotherapy and start cabozantinib now D. Re-initiate the nivolumab and ipilimumab as soon as possible and stop the steroid (no taper needed since she only received it for 1 week and no adrenal suppression is expected) E. Unsure