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1. The El Escorial criteria are used in clinical trials to provide a standard definition of patients with amyotrophic lateral sclerosis (ALS). Upper motor neuron (UMN) and lower motor neuron (LMN) signs are utilized in these criteria. Which of the following pairs includes examples of UMN and LMN signs, respectively?

A. Arm fasciculations and spasticity in legs B. Tongue fasciculations and atrophy in legs C. Spasticity in arms and atrophy in legs D. Spasticity in arms and spasticity in speech E. Unsure

2. For a patient with a diagnosis of amyotrophic lateral sclerosis (ALS), a genetic investigation may be helpful for clinical trial inclusion and other research. Which of the following is NOT true regarding genes and ALS?

A. Only familial ALS has genetic variants associated with risk of the disease B. Familial and sporadic ALS have known genetic variants associated with risk of the disease C. Approximately 90% of ALS cases are sporadic with no known family history of ALS D. There are clinical trials investigating characteristics and treatment for ALS patients with confirmed genetic mutation of C9ORF72 E. Unsure

3. AG is a 61-year-old female who has been receiving Intravenous immune globulin (IVIG) infusions for 6 months for lower extremity weakness diagnosed as chronic inflammatory demyelinating polyneuropathy (CIDP). She has experienced no improvement, so her IVIG infusion therapy is discontinued. She is diagnosed with amyotrophic lateral sclerosis (ALS). Which of the following factors does NOT contribute to the difficulty in diagnosing ALS?

A. ALS is diagnosed when other causes of signs and symptoms have been excluded B. Patient access to an experienced neurologist may be limited C. Delayed diagnosis may occur due to patient factors such as minimizing symptoms D. ALS presentation, symptoms, and progression are similar in most patients E. Unsure

Evaluation Questions

4. How confident are you in your decision about the diagnosis for AG in the question above?

A. Not at all confident B. Somewhat confident C. Confident D. Highly confident

Maintenance is scheduled for 8/7/2023 7:00 AM EST - 8:00 AM EST.

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2. For a patient with a diagnosis of amyotrophic lateral sclerosis (ALS), a genetic investigation may be helpful for clinical trial inclusion and other research. Which of the following is NOT true regarding genes and ALS?

Evaluation Questions

4. How confident are you in your decision about the diagnosis for AG in the question above?

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Maintenance is scheduled for 8/7/2023 7:00 AM EST - 8:00 AM EST.

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2. For a patient with a diagnosis of amyotrophic lateral sclerosis (ALS), a genetic investigation may be helpful for clinical trial inclusion and other research. Which of the following is NOT true regarding genes and ALS?

Evaluation Questions

4. How confident are you in your decision about the diagnosis for AG in the question above?

« Return to Activity

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