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1. Cannabidiol (CBD) directly binds to which specific receptor in the brain?

A. CB1 B. CB2 C. CB3 D. It does not bind directly to CB receptors E. Unsure

2. Which of the following correctly describes the formulation of Epidiolex?

A. Purified cannabidiol (CBD) plant product B. Synthetic CBD product C. Purified from hemp D. CBD that contains no tetrahydrocannabinol component E. Unsure

3. Epidiolex is approved for which type of epilepsy?

A. Focal onset seizures with secondary generalization B. Absence seizures C. Lennox-Gastaut syndrome and Dravet syndrome D. Juvenile myoclonic epilepsy E. Unsure

4. Which of the following is considered a Schedule I substance by the Drug Enforcement Administration (DEA)?

A. Epidiolex B. Cannabidiol (CBD) C. Marijuana D. B and C E. Unsure

5. Any unused Epidiolex oral solution should be discarded how many weeks after the bottle is opened by the consumer?

A. 8 weeks B. 12 weeks C. 26 weeks D. 52 weeks E. Unsure

6. Use the following CASE to answer questions 6 through 9.
CB is a 3-year-old boy diagnosed with Dravet syndrome (DS). His seizures began after a febrile illness when he was 11 months old. Since that time, his seizures have gotten worse and he has presented to the emergency department several times in status epilepticus (SE). Most days, he has 10 myoclonic seizures and at least 1 generalized tonic-clonic seizure. His current medications are stiripentol and clobazam orally. His serum chemistries and complete blood count are all within normal limits.

The provider asks for assistance with CB's medications, as he is unfamiliar with which anti-seizure drugs (ASDs) are approved by the United States Food and Drug Administration (FDA) for DS. Which of the following ASDs are FDA approved to treat DS?

A. Levetiracetam and stiripentol B. Lamotrigine and Epidiolex C. Epidiolex and stiripentol D. Clobazam monotherapy E. Unsure

7. CB's family is wondering what causes DS and how common it is. Which of the following choices below describes the pathophysiology and incidence of DS?

A. DS is thought to be caused by an SCN1A mutation; it has an incidence of approximately 1 in 20,000 to 1 in 40,000 B. DS is thought to be caused by a deletion of the sodium channel; it has an incidence of approximately 1 in 50,000 C. DS is thought to be caused by trauma; it has an incidence of approximately 1 in 20,000 to 1 in 40,000 D. DS is thought to be caused by a hypoxic event at birth; it has an incidence of approximately 1 in 20,000 to 1 in 60,000 E. Unsure

8. CB's provider has never ordered Epidiolex and is asking for specific information regarding the product. He is curious if he can advise the family to purchase cannabidiol (CBD) from a local dispensary instead of writing a prescription for Epidiolex. Which of the following choices below answers this question?

A. Epidiolex is a synthetic CBD derivative available as a 50-mg/mL oral solution; it can cause elevation in liver function tests (LFTs); it is the same as CBD from dispensaries B. Epidiolex is a purified plant CBD derivative available as a 100-mg/mL oral solution; it can cause elevation in LFTs; it is not the same as CBD from dispensaries C. Epidiolex is a synthetic CBD derivative available as a 100-mg/mL oral solution; it can cause elevation in LFTs; it is the same as CBD from dispensaries D. Epidiolex is a purified plant CBD derivative available as a 50-mg/mL oral solution; it can cause renal failure; it is the same as CBD from dispensaries E. Unsure

9. CB's provider starts Epidiolex at a dose of 2.5 mg/kg orally twice daily (5 mg/kg/day). If needed, what is the recommended interval to increase the dose of Epidiolex to 5 mg/kg twice daily?

A. The dose may be increased in 3 days B. The dose may be increased in 7 days C. The dose may be increased in 14 days D. The dose should never be increased: 5 mg/kg/day is the maximum dose E. Unsure

10. Which of the following statements regarding the use of Epidiolex is FALSE?

A. Any community pharmacy can dispense Epidiolex B. Patients should always use the adapter and oral dosing syringe that is provided with the product C. Patients may experience somnolence and sedation while on Epidiolex D. A patient using Epidiolex may test positive for cannabis if a drug screening is done E. Unsure

Evaluation Questions

11. How confident are you in your decision about treatment for CB in the question above?

A. Not at all B. Somewhat confident C. Confident D. Highly confident

Maintenance is scheduled for 8/7/2023 7:00 AM EST - 8:00 AM EST.

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1. Cannabidiol (CBD) directly binds to which specific receptor in the brain?

2. Which of the following correctly describes the formulation of Epidiolex?

3. Epidiolex is approved for which type of epilepsy?

4. Which of the following is considered a Schedule I substance by the Drug Enforcement Administration (DEA)?

5. Any unused Epidiolex oral solution should be discarded how many weeks after the bottle is opened by the consumer?

7. CB's family is wondering what causes DS and how common it is. Which of the following choices below describes the pathophysiology and incidence of DS?

9. CB's provider starts Epidiolex at a dose of 2.5 mg/kg orally twice daily (5 mg/kg/day). If needed, what is the recommended interval to increase the dose of Epidiolex to 5 mg/kg twice daily?

10. Which of the following statements regarding the use of Epidiolex is FALSE?

Evaluation Questions

11. How confident are you in your decision about treatment for CB in the question above?

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Maintenance is scheduled for 8/7/2023 7:00 AM EST - 8:00 AM EST.

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1. Cannabidiol (CBD) directly binds to which specific receptor in the brain?

2. Which of the following correctly describes the formulation of Epidiolex?

3. Epidiolex is approved for which type of epilepsy?

4. Which of the following is considered a Schedule I substance by the Drug Enforcement Administration (DEA)?

5. Any unused Epidiolex oral solution should be discarded how many weeks after the bottle is opened by the consumer?

7. CB's family is wondering what causes DS and how common it is. Which of the following choices below describes the pathophysiology and incidence of DS?

9. CB's provider starts Epidiolex at a dose of 2.5 mg/kg orally twice daily (5 mg/kg/day). If needed, what is the recommended interval to increase the dose of Epidiolex to 5 mg/kg twice daily?

10. Which of the following statements regarding the use of Epidiolex is FALSE?

Evaluation Questions

11. How confident are you in your decision about treatment for CB in the question above?

« Return to Activity

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