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1. Which of the following best describes resistance to β-lactams in P. aeruginosa?

A. Resistance is common with traditional β-lactams (e.g. cefepime), but has not yet been demonstrated with novel β-lactams (e.g. ceftolozane/tazobactam) B. Piperacillin/tazobactam resistant isolates almost always remain susceptible to meropenem C. Cross-resistance between β-lactams in P. aeruginosa is common D. Cefepime is consistently the most active β-lactam against P. aeruginosa

2. Which of the following is correct regarding the RESTORE-IMI 2 trial?

A. Imipenem/cilastatin/relebactam was associated with a greater number of adverse events leading to treatment discontinuation compared with piperacillin/tazobactam B. Imipenem/cilastatin/relebactam was associated with a non-inferior 28-day all-cause mortality from HAP or VAP compared with piperacillin/tazobactam C. Imipenem/cilastatin/relebactam was not shown to be effective in critically ill, high-risk patients D. Piperacillin/tazobactam was shown to have a more favorable clinical response at early follow-up compared to imipenem/cilastatin/relebactam

3. JL is a 65-year-old woman who has been empirically treated for sepsis with piperacillin/tazobactam for the past five days. Today she develops a high fever and increased purulent secretions. Respiratory cultures identify P. aeruginosa and susceptibilities are currently pending. Which agent is the best choice to switch JL to?

A. Meropenum B. Imipenem/cilastatin/relebactam C. Cefepime D. Ceftazidime

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