A. Diphenoxylate/atropine because this is likely cholinergic-mediated B. Loperamide 2 mg every 2 hours until diarrhea-free for 12 hours C. Prednisone 1 mg/kg PO daily; re-evaluate in 3 days for improvement D. This is expected; drink lots of Gatorade until it improves in a few days E. Unsure

A. Permanently discontinue nivolumab and start dacarbazine (850 mg/m2 IV weeks 1, 4, 7, & 10) B. Restart nivolumab at the same dose (360 mg q3week) C. Dose reduce nivolumab 50% and add ipilimumab 3mg/kg IV q3week D. Dose reduce the nivolumab to 50% of the prior dose (180mg q3week) E. Unsure

A. Chemotherapy toxicity rarely leads to treatment discontinuation, while monotherapy PD1 inhibitor toxicity commonly leads to discontinuation B. Immunotherapy has multiple drug interactions that can lead to increased toxicity, while few drug interactions exist for chemotherapy C. Cycle 1 toxicity with immunotherapy predicts the tolerability moving forward, but chemotherapy-related toxicity is less predictable D. Rapid diagnosis and early intervention will minimize an immunotherapy-related toxicity like diarrhea, but not chemotherapy-associated neutropenia E. Unsure

A. Give all patients a prescription for prednisone with cycle 1 to take when needed B. Educate clinical and non-clinical staff about irAEs and how to manage patients seeking help C. Create a standalone clinic to see and manage all immunotherapy patients D. Connect patients with a specialty pharmacy to manage treatment-related toxicity needs E. Unsure

A. They predict poor outcomes B. They are all dose dependent C. They can be permanent D. Their time to onset is predictable E. Unsure