A. The American Society of Clinical Oncology (ASCO) Value Framework is the only model recommended for determining the value of cancer therapies B. The National Comprehensive Cancer Network (NCCN) Evidence Blocks are the most widely used framework in the health plan arena in managed care settings C. Only the ASCO, European Society for Medical Oncology (ESMO), and Institute for Clinical and Economic Review (ICER) value assessment frameworks are currently recommended in the managed care settings D. The ASCO, ESMO, NCCN, ICER, and MSKCC value assessment frameworks are all available currently, but ICER is used most commonly E. I'm not sure

A. Multiple alternative payment models are available to manage and compare PARP inhibitors in different cancer settings B. Current oncology value models incorporate newer approvals and indications for all the PARP inhibitors C. Lack of real-world evidence makes it difficult to assess value and compare cost of PARP inhibitors D. All oncology value models overestimate the value of long-term survival of PARP inhibitors in pancreatic cancer E. I'm not sure

A. Minimal improvement in PFS independent of platinum sensitivity status B. Significant improvement in PFS only in cancers with non-BRCA homologous recombination deficiency (HRD) mutations C. Significant improvement in PFS, particularly in cancers with a germline BRCA mutation D. Improvement in PFS, but majority of patients discontinued treatment because of severe treatment-emergent adverse events E. I'm not sure

A. FoundationOne loss of heterozygosity (LOH) test B. myChoice test C. Indirect HRD/LOH test D. I'm not sure

A. Would not recommend a PARP inhibitor due to lack of substantial clinical benefits over alternative therapies B. Would recommend biomarker testing at diagnosis and before initiating PARP inhibitor therapy C. Would not recommend a PARP inhibitor due to higher cost and lack of real-world evidence D. Would recommend a PARP inhibitor and initiate adherence and split-fill programs to assess drug tolerability E. I'm not sure