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1. Which of the following best describes the 2021 IDSA/SHEA clinical practice recommendation for the treatment of adults with an initial mild-moderate episode of C. difficile infection?

A. Metronidazole, vancomycin, and fidaxomicin are recommended with no preference for any agent B. Metronidazole and vancomycin are recommended over fidaxomicin C. Fidaxomicin is preferred over vancomycin D. Metronidazole is recommended over vancomycin and fidaxomicin

2. In a post-hoc analysis of data from the MODIFY I/II clinical trials of bezlotoxumab, which patient population demonstrated the greatest reduction in rates of recurrent C. difficile infection after receipt of bezlotoxumab?

A. All patients, regardless of risk factors for recurrent C. difficile infection B. Patients hospitalized with C. difficile infection and patients with a history of inflammatory bowel disease C. Patients with 3 or more pre-specified risk-factors for recurrent C. difficile infection D. Patients with over 5 risk-factors for recurrent C. difficile infection

3. A 57-year-old woman presents with a confirmed episode of C. difficile after completing a course of azithromycin for dental work. She notes that she immediately recognized her symptoms because she was treated for initial and recurrent episodes of C. difficile 9 months ago. She is otherwise healthy and is concerned that a trip to South America to visit her grandchildren may have contributed to this episode. Which of the following is the most important risk factor for a future recurrence in this woman?

A. Her age B. Recent travel abroad C. Treatment with azithromycin D. A previous recurrence

4. The increased risk of recurrence with vancomycin compared with fidaxomicin is likely due to:

A. Increased resistance against vancomycin B. Decreased toxin B production associated with fidaxomicin C. Alterations in the gut microbiota caused by vancomycin D. Enrichment of Bacteroidetes by vancomycin

5. A 67-year-old man presents with a sudden onset of diarrhea with 6-9 bowel movements per day along with abdominal pains. His stool tested positive for C. difficile. What therapy would you recommend for him?

A. Fidaxomicin, 200 mg, twice daily for 10 days B. Metronidazole, 500 mg, 3 times per day for 10 days C. Vancomycin, 125 mg, 4 times per day for 10 days D. Vancomycin in a pulsed regimen

Maintenance is scheduled for 8/7/2023 7:00 AM EST - 8:00 AM EST.

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1. Which of the following best describes the 2021 IDSA/SHEA clinical practice recommendation for the treatment of adults with an initial mild-moderate episode of C. difficile infection?

2. In a post-hoc analysis of data from the MODIFY I/II clinical trials of bezlotoxumab, which patient population demonstrated the greatest reduction in rates of recurrent C. difficile infection after receipt of bezlotoxumab?

4. The increased risk of recurrence with vancomycin compared with fidaxomicin is likely due to:

5. A 67-year-old man presents with a sudden onset of diarrhea with 6-9 bowel movements per day along with abdominal pains. His stool tested positive for C. difficile. What therapy would you recommend for him?

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Maintenance is scheduled for 8/7/2023 7:00 AM EST - 8:00 AM EST.

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1. Which of the following best describes the 2021 IDSA/SHEA clinical practice recommendation for the treatment of adults with an initial mild-moderate episode of C. difficile infection?

2. In a post-hoc analysis of data from the MODIFY I/II clinical trials of bezlotoxumab, which patient population demonstrated the greatest reduction in rates of recurrent C. difficile infection after receipt of bezlotoxumab?

4. The increased risk of recurrence with vancomycin compared with fidaxomicin is likely due to:

5. A 67-year-old man presents with a sudden onset of diarrhea with 6-9 bowel movements per day along with abdominal pains. His stool tested positive for C. difficile. What therapy would you recommend for him?

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