1. A 59-year-old man has been hospitalized following a myocardial infarction and requires mechanical ventilation. After 4 days in the ICU, he develops fever and a chest radiograph reveals new pulmonary infiltrates. Culture from a BAL sample identifies P. aeruginosa. The ICU has experienced a recent outbreak of multidrug-resistant P. aeruginosa exhibiting upregulation of MexAB. Which of the following antimicrobials would be most likely to retain activity against this pathogen?

2. Inducible AmpC producers will typically exhibit initial susceptibility followed by resistance after repeated exposure to which of the following antimicrobials?

3. According to the latest IDSA treatment guidance, preferred antimicrobial therapy for bacteremia caused by an organism with a high risk of inducible AmpC production (e.g., E. cloacae) is:

4. Which of the following newer antimicrobials exhibits in vitro activity against organisms that produce a metallo-beta-lactamase?

5. During microbiologic screening for resistant phenotypes, an ESBL-producing organism will demonstrate diminished susceptibility to which of the following classes of antimicrobials?

« Return to Activity