A. Defined as residual viable tumor ≤10% in resection cavity and lymph nodes B. It is common with a median frequency in neoadjuvant trials being >60% C. Defined as absence of residual viable tumor cells on pathologic examination after neoadjuvant chemotherapy D. It is an emerging surrogate endpoint due to the limited utility of major pathologic response E. Unsure

A. CheckMate 816 included patients with stage IB (≥4 cm)-IIIC NSCLC B. The primary endpoints were complete pathologic response and major pathologic response C. Sensitizing EGFR mutation– and ALK alteration–positive patients were included D. Patients were randomized to either neoadjuvant nivolumab Q3W + chemotherapy Q3W x 3 cycles or chemotherapy alone Q3W x 3 cycles E. Unsure

A. The addition of neoadjuvant nivolumab to chemotherapy was associated with a significant increase in pathologic complete response compared to chemotherapy alone B. AK will have less of a chance of pathologic complete response (pCR) with the addition of nivolumab to chemotherapy as her neoadjuvant therapy due to her PD-L1 score C. Based on the results of CheckMate 816, AK can be offered a chemotherapy-sparing regimen with immunotherapy monotherapy D. In CheckMate 816, the rate of R0 resection was less with nivolumab + chemotherapy compared to chemotherapy alone E. Unsure

A. Consult a gastroenterologist for consideration of fecal transplant B. Admit AK to the hospital for frequent monitoring and initiate methylprednisolone 40 mg IV BID C. Admit AK to the hospital for frequent monitoring and initiate prednisone 40 mg PO once daily D. Recommend patient purchase loperamide over the counter and discharge home E. Unsure

A. Taper steroids slowly over at least 4 to 6 weeks. Pneumocystis jirovecii pneumonia (PJP) prophylaxis should be initiated. The patient should be instructed to call her oncology team if there are any signs of worsening diarrhea B. Steroids should be rapidly tapered to avoid corticosteroid-induced adverse effects. A taper over 1 week is reasonable with no PJP prophylaxis necessary C. The inpatient medical team should stop steroids and administer 5 mg/kg of infliximab just prior to discharge D. Steroids should be tapered over 4 to 6 weeks with close monitoring. Herpes simplex virus (HSV), fungal, and PJP prophylaxis should be initiated given the level and duration of immunosuppression with the recommended steroid taper E. Unsure