1. Which of the following is the best summary of the mechanism of action of combined lymphocyte-activation gene 3 (LAG-3) and programmed cell death-1 (PD-1) blockade?

2. Which of the following combinations was shown to be effective in prolonging survival when used for first-line treatment of melanoma with asymptomatic metastases to the brain in the phase 2 CheckMate 204 trial?

3. DL is a 64-year-old man with BRAF V600E-mutated metastatic melanoma of the liver, lungs, and bone. Of note, his lactate dehydrogenase (LDH) is elevated (780 U/L). He presents to the medical oncology clinic for initial evaluation. He has grade 2 fatigue and bone pain but is in no acute distress. Before arriving, DL read about BRAF and MEK inhibitors on the internet after finding out his tumor had a BRAF V600E mutation. He is curious about whether he should start a BRAF/MEK doublet combination to improve his bone pain. The phase 3 DREAMseq trial compared first-line BRAF/MEK inhibition with first-line combination immune checkpoint inhibitor blockade. At an interim analysis, one of the treatment arms demonstrated 20% lower 2-year OS, triggering the study to stop early. Which of the following DREAMseq treatment arms had the LOWEST 2-year OS and should be avoided in DL as first-line treatment?

4. According to the RELATIVITY-047 trial, which of the following combination treatments demonstrated extended PFS when compared with nivolumab in patients with untreated metastatic melanoma?

5. TJ is a 59-year-old woman with BRAF V600K-mutated stage IIIC melanoma that was resected 6 weeks ago. She presents to the medical oncology clinic for consideration for adjuvant treatment and has requested a treatment with the lowest rate of treatment-related side effects. Which of the following approved treatment options for adjuvant treatment of resected stage III melanoma has the lowest rate of severe treatment-related AEs and would be the most appropriate choice of therapy for TJ based on her request?

Evaluation Questions

6. How confident are you in your treatment choice for TJ in the question above?

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