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1. What is the correct match of maintenance agent and its mechanism of action?

A. Azacitidine – IDH2 inhibitor B. Sorafenib – FLT3-TKD inhibitor C. Midostaurin – FLT3-ITD and FLT3-TKD inhibitor D. Enasidenib – FLT3-ITD inhibitor E. Unsure

2. Which of the following is true regarding oral azacitidine?

A. Oral azacitidine is 100% bioavailable and may be used interchangeably with IV/SQ azacitidine. B. Major toxicities of oral azacitidine include nausea and/or vomiting, diarrhea, and cytopenias. C. The majority of patients in the QUAZAR trial received 3 to 4 consolidation cycles prior to maintenance therapy, the standard of care in AML patients. D. Oral azacitidine should be used in all AML patients, regardless of induction chemotherapy. E. Unsure

3. Which of the following is true regarding the FLT3i used as maintenance therapy in AML?

A. Midostaurin should be used at the full dose in combination with azole antifungals, given the high risk of mold infections in AML patients. B. Sorafenib should be given with anti-emetic premedication and with food to mitigate the risk for nausea and/or vomiting. C. Sorafenib is the drug of choice for patients with FLT3-TKD mutations, given the improvement in overall survival seen in this setting. D. Midostaurin requires dose adjustments for concomitant strong CYP3A4 inhibitors, including azole antifungals. E. Unsure

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