1. Which of the following is TRUE regarding the mechanisms of action of narcolepsy drugs?

2. Which of the following symptom combinations would best support a narcolepsy diagnosis?

3. A 36-year-old male with narcolepsy treated with dextroamphetamine has recently been diagnosed with hypertension. Despite optimization of a thiazide and acetylcholinesterase inhibitor, his daily blood pressure journal shows that his systolic blood pressure is consistently between 150-170 mmHg. The decision is made to discontinue his dextroamphetamine and begin a different medication for his narcolepsy. Which of the following is the most appropriate agent to initiate?

4. Which of the following tools can clinicians use to evaluate the effectiveness of pharmacological and non-pharmacological interventions for excessive daytime sleepiness in narcolepsy and other sleeping disorders?

5. Use the following CASE for questions 5 and 6:
GY is a 30-year-old male who presents with complaints of excessive daytime sleepiness for approximately 6 months. His decision to seek care was due to concerns over repeated, transient episodes of slurred speech, bilateral facial sagging, and partial loss of muscle tone that began one week ago. Another provider determined that GY has not experienced a stroke. A recent MSLT indicated an average sleep latency of 5 minutes and GY’s CSF hypocretin level is 90 pg/mL

Which of the following is the most appropriate diagnosis for GY?

6. GY also presents with hepatic impairment (Child-Pugh Class B). Which of the following narcolepsy medications can be prescribed to GY without dose adjustment?

7. A 19-year-old female with Narcolepsy Type II wants to begin taking oral contraceptives. Her symptoms have been well controlled for 2 years with modafinil 200 mg by mouth every morning. What is the most appropriate modification to this patient's regimen?

8. Which medication is FDA approved to treat cataplexy?

9. Which of the following is NOT classified as a federally controlled substance?

10. Which of the following drugs for narcolepsy is contraindicated in patients with succinic semialdehyde dehydrogenase deficiency?

« Return to Activity