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FACULTY

Sarah A. Spinler, PharmD, FCCP, FAHA, FASHP, AACC, BCPS AQ Cardiology
School of Pharmacy and Pharmaceutical Sciences
Binghamton University
Binghamton, New York

FINANCIAL DISCLOSURE

Sarah A. Spinler, PharmD, FCCP, FAHA, FASHP, AACC, BCPS AQ Cardiology, has indicated the following relevant affiliation or financial relationship with a commercial interest: Consultant—Portola, Speaker's Bureau—Bristol Myers Squibb.

The following reviewer, A. Shaun Rowe, hereby states he has indicated the following relevant affiliation or financial relationship with a commercial interest: Speaker's Bureau—Chiesi and Portola.

Susanne Batesko, RN, BSN, Robin Carrino, and L. Michael Posey, BSPharm, MA, as well as the planners, managers, and other individuals, not previously disclosed, who are in a position to control the content of Postgraduate Healthcare Education (PHE) continuing education (CE) activities hereby state that they have no relevant conflicts of interest and no financial relationships or relationships to products or devices during the past 12 months to disclose in relation to this activity.  PHE is committed to providing participants with a quality learning experience and to improve clinical outcomes without promoting the financial interests of a proprietary business.

ACCREDITATION STATEMENTS

PHARMACY
Postgraduate Healthcare Education, LLC is accredited by the Accreditation Council for Pharmacy Education as a provider of continuing pharmacy education.
UAN: 0430-0000-18-033-H05-P
Credits: 2.0 hours (0.20 ceu)

Type of Activity: Knowledge
Media: Internet

Fee Information: There is no fee for this educational activity.

Estimated time to complete activity: 120 minutes

Published

June 30, 2018

Expires

June 30, 2020

TARGET AUDIENCE

This accredited activity has been designed for pharmacists.

HOW TO EARN CREDIT

During the period June 30, 2018, through June 30, 2020, participants must 1) read the learning objectives and faculty disclosures; 2) study the educational activity; and 3) complete the post-test and the evaluation form. To answer the questions, click on your selected choice for each answer then proceed to the next question. Once completed, click on Grade Exam at the bottom of the page. Your post-test will automatically be graded. If you successfully complete the post-test (score of 70% or higher), your statement of participation will be made available immediately. Click on the View Statement of Participation link and print the statement for your records. If you receive a score lower than 70%, you will receive a message notifying you that you did not pass the post-test. You will have 2 opportunities to pass the post-test. To receive Credit, you must provide your date of birth and NABP number. All Credit information will be uploaded into CPE monitor within 30 days.

GOAL

To inform and educate pharmacists about the management of patients who require reversal of direct oral anticoagulants (DOACs) because of major bleeding, emergency surgery, or an urgent procedure; educated pharmacists on management of these patients, including interpreting laboratory assays and use of pharmacologic agents; and review investigational agents for DOAC reversal.

EDUCATIONAL OBJECTIVES

Upon completion of this program, participants should be better able to:

1. Identify rates of major bleeding and risk factors for bleeding in patients taking direct oral anticoagulants (DOACs).
2. Identify the qualitative and quantitative blood coagulation tests for DOACs.
3. Explain the mechanisms of action of idarucizumab and andexanet alfa for reversing bleeding associated with DOAC therapy.
4. Discuss the appropriate dosing and administration of idarucizumab for dabigatran-associated bleeding reversal.
5. Discuss the appropriate dosing and administration of andexanet alfa for factor Xa inhibitor reversal.
6. Review the appropriate use of alternative agents used for reversal of factor Xa inhibitors.
7. List investigational agents for DOAC reversal.

REQUIRED COMPUTER HARDWARE/SOFTWARE

Please ensure the computer system you plan to use meets the following minimum requirements:

• Operating System: Windows 98 or higher & Macintosh 2.2 or higher
  
• Internet Browser (Mac &/ Windows): Internet Explorer 6.0 or higher, Google Chrome, Safari 5.0.6 or higher, Firefox 3.0.3 or higher & Opera 5 or higher
• Broadband Internet connection: Cable, High-speed DSL & any other medium that is internet accessible
• Peripherals: Computer speakers or headphones
• Monitor Screen Resolution: 320 x 480 or higher
• Media Viewing Requirements: Adobe Reader, Microsoft PowerPoint, Flash Player & HTML5

Disclosure of Unlabeled Use and Disclaimer:

The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of Postgraduate Healthcare Education, LLC and Portola. Participants have an implied responsibility to use the newly acquired information to enhance patient outcomes and their own professional development. The information presented in this activity is not meant to serve as a guideline for patient management. Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this activity should not be used by clinicians without an evaluation of their patients' conditions and current medications, including the identification of possible contraindications regarding the dangers of use and a review of any applicable manufacturer's product information, as well as a comparison with the recommendations of other authorities.

The author, sponsor, and publisher of this continuing education activity have made all reasonable efforts to ensure that all information contained herein is accurate in accordance with the latest available scientific knowledge at the time of acceptance for publication. However, because information regarding drugs (their administration, dosages, contraindications, adverse reactions, interactions, special warnings, precautions, etc.) is subject to constant change, the reader is advised to check the manufacturer's package insert for information concerning recommended dosages and potential problems and cautions prior to dispensing or administering the drug. Special precautions should be taken when a drug is new, or highly toxic, or is unfamiliar to the dispenser or administrant. This educational activity may contain discussion of published and/or investigational uses of agents that are not approved by the U.S. Food and Drug Administration (FDA). Neither the publisher nor sponsor promotes the use of any agent outside of approved labeling. Statements made in this monograph have not been evaluated by the FDA. Nutritional products discussed are not intended for the diagnosis, treatment, cure, or prevention of any disease.