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This activity is jointly provided by

This activity is supported by an educational grant from Alexion Pharmaceuticals, Inc.

Statement of Need/Program Overview

When and how to use specific direct oral anticoagulant (DOAC) reversal agents is not straightforward. Two major professional societies (eg, the American College of Cardiology [ACC] and the American College of Emergency Physicians [ACEP]) issued expert panel recommendations for anticoagulant reversal only within the last year. In addition, reports of real-world experience with prothrombin complex concentrates (PCCs) for DOAC reversal have been published in the recent past, potentially prompted by familiarity with PCCs to reverse warfarin among other factors. Furthermore, evaluating whether and when to restart anticoagulation therapy is an important part of managing a patient with a DOAC-associated bleed. Join us in this E-monograph activity to explore these topics by a comprehensive review of evidence-based practice guidelines and real-world data around clinical outcomes for DOAC reversal. The goal of this activity is to educate hospital and health-system pharmacists about: (1) updated guidance for using specific DOAC reversal agents in patients with DOAC-associated bleeding, including how to measure patient anticoagulant activity and how to dose specific DOAC reversal agents; (2) emerging data and guidance regarding outcomes and cost with specific DOAC reversal agents and nonspecific PCCs; and (3) recommendations about whether and when to restart anticoagulation therapy after a bleed.

target audience

The audience for the activity will consist of hospital and health-system pharmacists.

Release date

February 18, 2022

expiration date

February 18, 2023

educational objectives

After completing this activity, the participant should be better able to:

  • REVIEW the guidelines for using specific DOAC reversal agents
  • EVALUATE emerging data regarding outcomes and cost with specific DOAC reversal agents compared with PCCs
  • SUMMARIZE recommendations about whether and when to restart anticoagulation therapy


James S. Kalus, PharmD, FASHP
Director of Pharmacy
Henry Ford Health System
Adjunct Assistant Professor of Pharmacy and Medicine
Wayne State University
Detroit, MI

Darius Faison, PharmD, BCPS
Clinical Specialist, Emergency Medicine
Henry Ford Wyandotte Hospital
Wyandotte, MI

Pharmacist Accreditation Statement

acpeGlobal Education Group is accredited by the Accreditation Council for Pharmacy Education as a provider of continuing pharmacy education.

Credit Designation

Global Education Group designates this continuing education activity for 0.5 contact hour(s) (0.05 CEUs) of the Accreditation Council for Pharmacy Education. (Universal Activity Number - 0530-9999-22-001-H01-P)

This is a knowledge-based activity.

Global Contact Information

For information about the accreditation of this program, please contact Global at 303-395-1782 or cme@globaleducationgroup.com.

Instructions to Receive Credit

In order to receive ACPE credits, participants must complete the pre-assessment questions, post-assessment, and program evaluation within a maximum of 60 days of participating in the activity. To answer the questions, click on your selected choice for each answer then proceed to the next question. Once completed, click on the Grade Exam button at the bottom of the page. Your post-assessment will automatically be graded. If you successfully complete the post-assessment (score of 70% or higher), your statement of participation will be made available immediately. Click on the View Statement of Participation link and print the statement for your records. If you receive a score lower than 70%, you will receive a message notifying you that you did not pass the post-assessment. You will have 2 opportunities to pass the post-assessment. To receive Credit, you must provide your date of birth and NABP number. All Credit information will be uploaded into CPE monitor within 30 days. Your online participation statement will be saved within your PowerPak account, which you can access at any time by logging in and clicking on "Exam History".

System Requirements

Please ensure the computer system you plan to use meets the following minimum requirements:

  • Operating System: Windows 98 or higher & Macintosh 2.2 or higher
  • Internet Browser (Mac & Windows): Internet Explorer 6.0 or higher, Google Chrome, Safari 5.0.6 or higher, Firefox 3.0.3 or higher, & Opera 5 or higher
  • Broadband Internet connection: Cable, High-speed DSL & any other medium that is internet accessible
  • Peripherals: Computer speakers or headphones
  • Monitor Screen Resolution: 320 x 480 or higher
  • Media Viewing Requirements: Adobe Reader, Microsoft PowerPoint, Flash Player & HTML5

Fee Information & Refund/Cancellation Policy

There is no fee for this educational activity.

Disclosures of Conflicts of Interest

Global Education Group (Global) adheres to the policies and guidelines, including the Standards for Integrity and Independence in Accredited CE, set forth to providers by the Accreditation Council for Continuing Medical Education (ACCME) and all other professional organizations, as applicable, stating those activities where continuing education credits are awarded must be balanced, independent, objective, and scientifically rigorous. All persons in a position to control the content of an accredited continuing education program provided by Global are required to disclose all financial relationships with any ineligible company within the past 24 months to Global.  All financial relationships reported are identified as relevant and mitigated by Global in accordance with the Standards for Integrity and Independence in Accredited CE in advance of delivery of the activity to learners. The content of this activity was vetted by Global to assure objectivity and that the activity is free of commercial bias. 

All relevant financial relationships have been mitigated.

The faculty have the following relevant financial relationships with ineligible companies:

Name of Faculty or Presenter Reported Financial Relationship
James S. Kalus, PharmD, FASHP Nothing to disclose
Darius Faison, PharmD, BCPS Nothing to disclose

The planners and managers have the following relevant financial relationships with ineligible companies:

Name of Planner or Manager Reported Financial Relationship
Lindsay Borvansky Nothing to disclose
Andrea Funk Nothing to disclose
Liddy Knight Nothing to disclose
Ashley Cann Nothing to disclose
Andrew Kim Nothing to disclose
Kimberly Miniter Nothing to disclose
Mary Simmons Nothing to disclose

Disclosure of Unlabeled Use

This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. Global Education Group (Global) and Spire Learning do not recommend the use of any agent outside of the labeled indications.

The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of any organization associated with this activity. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.


Participants have an implied responsibility to use the newly acquired information to enhance patient outcomes and their own professional development. The information presented in this activity is not meant to serve as a guideline for patient management. Any procedures, medications, or other courses of diagnosis or treatment discussed in this activity should not be used by clinicians without evaluation of patient conditions and possible contraindications on dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities.