A. Volume of insulin dose is physically too large for a single SC administration B. Patient cannot manipulate vials and syringes C. Multiple injections are required to deliver a single insulin dose D. Discomfort E. Unpredictable insulin absorption

A. Using a U100 syringe, draw to the 50 units marking B. Using a U100 syringe, draw to the 25 units marking C. Using a tuberculin syringe, draw 0.2 mL D. Using a tuberculin syringe, draw 0.4 mL

A. Avoid using insulin as a “threat” and discuss it as an option early B. Dose NPH insulin twice daily to minimize hypoglycemia C. Use insulin pens and regimens that offer maximum flexibility D. Give a “limited” trial of insulin

A. It is associated with less nocturnal hypoglycemia B. It has a flatter PK profile and a duration of action ≤36 hrs C. It is only available in a pen with 1.5 mL of U300 glargine D. Current pen allows for a max of 240 units of insulin per shot E. Patients switching from twice daily NPH to U300 glargine should start with 80% of total daily NPH dosage