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New Therapeutic Options for Multiple Sclerosis: An Update for Specialty and Managed Care Pharmacy

Table 1: Average Wholesale Price
Brand� Name Generic Name Unit Dose Price Per Unit Frequency �Price per 4 weeks Price per year (52 weeks)
Avonex1 Interferon β-1a 30 mcg (1 dose) $1,600.80 Once Weekly $6,403.20 $83,241.60
  30 mcg/0.5 mL (0.5 mL dose) $6,403.20 $25,612.80 $332,966.40
Rebif2 Interferon β-1a 22 or 44 mcg/0.5 mL (0.5 mL dose) $575.97 3 Times Weekly $6,911.64 $89,851.32
Plegridy3 Interferon β-1a 125 mcg/0.5 mL (0.5 mL dose) $3,201.60 Every 14 Days $6,403.20 $83,241.60
Betaseron4 Interferon β-1b 0.3 mg (1 dose) $484.10 Every Other Day $6,777.40 $88,106.20
Extavia5 Interferon β-1b 0.3 mg (1 dose) $403.87 Every Other Day $5,654.18 $73,504.34
Glatopa6 Glatiramer Acetate 20 mg/mL (1mL dose) $216.41 Once Daily $6,059.48 $78,773.24
Copaxone7 Glatiramer Acetate 20 mg/mL (1 mL dose) $244.42 Once Daily $6,843.76 $88,968.88
  40 mg/mL (1 mL dose) $500.80 3 Times Weekly $6,009.60 $78,124.80
Novantrone8 Mitoxantrone 20 mg/10 mL (10 mL dose) $303.53 Every 3 Months $101.18 $1,315.34
  25 mg/12.5 mL (12.5 mL dose) $324.71 Every 3 Months $108.24 $1,407.12
  30 mg/15 mL (15 mL dose) $409.42 Every 3 Months $136.47 $1,774.11
Tysabri9 Natalizumab 300 mg/15 mL (15 mL dose) $6,309.60 Once Monthly $6,309.60 $82,024.80
Lemtrada10 Alemtuzumab 12mg/1.2mL (1.2mL dose) $23,700 5 Doses in Year 1 $9,115.38 $118,500
  3 Doses/ Year in Consecutive Years $5,469.23 $71,100
Gilenya11 Fingolimod 0.5 mg (30 tablets) $233.25 Once Daily $6,530.96 $84,902.51
Aubagio Teriflunomide 7 mg and 14 mg tablets N/A Once Daily N/A N/A
Tecfidera12 Dimethyl fumarate 120 mg, delayed release (14 capsules) $115. 71 Twice Daily $6,480.00 $84,240.00
  120 mg or 240 mg (60 tablets) $115.76 $6,482.56 $84,273.28

1. Avonex. Lexicomp Online Lexi-Comp. 2015. Accessed November 12, 2015. 2. Rebif. Lexicomp Online Lexi-Comp. 2015. Accessed November 12, 2015.
3. Plegridy. Lexicomp Online Lexi-Comp. 2015. Accessed November 12, 2015. 4. Betaseron. Lexicomp Online Lexi-Comp. 2015. Accessed November 12, 2015.
5. Extavia. Lexicomp Online Lexi-Comp. 2015. Accessed November 12, 2015. 6. Glatopa. Lexicomp Online Lexi-Comp. 2015. Accessed November 12, 2015.
7. Copaxone. Lexicomp Online Lexi-Comp. 2015. Accessed November 12, 2015. 8. Novantrone. Lexicomp Online Lexi-Comp. 2015. Accessed November 12, 2015.
9. Tysabri. Lexicomp Online Lexi-Comp. 2015. Accessed November 12, 2015. 10. Lemtrada. Lexicomp Online Lexi-Comp. 2015. Accessed November 12, 2015.
11. Gilenya. Lexicomp Online Lexi-Comp. 2015. Accessed November 12, 2015. 12. Tecfidera. Lexicomp Online Lexi-Comp. 2015. Accessed November 12, 2015.


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